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Magnetic resonance in medicine

Molecular, dynamic, and structural origin of inhomogeneous magnetization transfer in lipid membranes.


PMID 27029318

Abstract

To elucidate the dynamic, structural, and molecular properties that create inhomogeneous magnetization transfer (ihMT) contrast. Amphiphilic lipids, lamellar phospholipids with cholesterol, and bovine spinal cord (BSC) specimens were examined along with nonlipid systems. Magnetization transfer (MT), enhanced MT (eMT, obtained with double-sided radiofrequency saturation), ihMT (MT - eMT), and dipolar relaxation, T The amplitude of ihMT ratio (ihMTR) is positively correlated with T Concerted motions of phospholipids in white matter decrease proton spin diffusion leading to increased proton T

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