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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Inflammatory Osteoclasts Prime TNFα-Producing CD4


PMID 27161765

Abstract

Bone destruction is a hallmark of chronic rheumatic diseases. Although the role of osteoclasts in bone loss is clearly established, their implication in the inflammatory response has not been investigated despite their monocytic origin. Moreover, specific markers are lacking to characterize osteoclasts generated in inflammatory conditions. Here, we have explored the phenotype of inflammatory osteoclasts and their effect on CD4