Surgical endoscopy

Effectiveness of laparoscopic stomach-partitioning gastrojejunostomy for patients with gastric outlet obstruction caused by advanced gastric cancer.

PMID 27287913


Distal advanced gastric cancer (AGC) occasionally causes gastric outlet obstruction (GOO). We developed a laparoscopic stomach-partitioning gastrojejunostomy (LSPGJ) to restore the ability of food intake. This was a retrospective study performed at a single institution. Of consecutive 78 patients with GOO caused by AGC between 2006 and 2012, 43 patients who underwent LSPGJ were enrolled. The procedure was performed in an antiperistaltic Billroth II fashion, and the afferent loop was elevated and fixed along the staple line of the proximal partitioned stomach. Then, patients for whom R0 resection was planned received chemotherapy prior to laparoscopic gastrectomy. The primary end point was food intake at the time of discharge, which was evaluated using the GOO scoring system (GOOSS). Short- and long-term outcomes were assessed as secondary end points. Overall survival was estimated and compared between the groups who received neoadjuvant chemotherapy followed by surgery (NAC group), definitive chemotherapy followed by curative resection (Conversion group), and best supportive care (BSC group). The median operative time was 92xa0min, blood loss did not exceed 30xa0g in any patient, and postoperative complications (Clavien-Dindo gradexa0≥2) were only seen in four patients (9.3xa0%). The median time to food intake was 3xa0days, and GOOSS scores were significantly improved in 41 patients (95.3xa0%). Chemotherapy was administered to 38 patients (88.4xa0%), of whom 11 later underwent radical resection, and 4 of 11 patients underwent conversion surgery following definitive chemotherapy. Median survival times were significantly superior in the NAC (nxa0=xa07; 46.8xa0months) and Conversion (nxa0=xa04; 35.9xa0months) groups than in the BSC group (nxa0=xa026; 12.2xa0months); however, the difference was not significant between the Conversion and NAC groups. LSPGJ is a feasible and safe minimally invasive induction surgery for patients with GOO from surgical and oncological perspectives.

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N,O-Bis(trimethylsilyl)carbamate, ≥98.0% (T)