Allergology international : official journal of the Japanese Society of Allergology

Lung sound analysis can be an index of the control of bronchial asthma.

PMID 27312512


We assessed whether lung sound analysis (LSA) is a valid measure of airway obstruction and inflammation in patients with bronchial asthma during treatment with inhaled corticosteroids (ICSs). 63 good adherence patients with bronchial asthma and 18 poor adherence patients were examined by LSA, spirometry, fractional exhaled nitric oxide (FeNO), and induced sputum. The expiration-to-inspiration lung sound power ratio at low frequencies between 100 and 200xa0Hz (E/I LF) obtained by LSA was compared between healthy volunteers and bronchial asthma patients. Next, post-ICS treatment changes were compared in bronchial asthma patients between the good adherence patients and the poor adherence patients. E/I LF was significantly higher in bronchial asthma patients (0.62xa0±xa00.21) than in healthy volunteers (0.44xa0±xa00.12, pxa0