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The Journal of asthma : official journal of the Association for the Care of Asthma

Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity.


PMID 27337146

Abstract

This study was to investigate whether the metabolic abnormalities of adipokines and asymmetrical dimethylarginine (ADMA) associate with pulmonary function deficits in adolescents with obesity and asthma. This study enrolled 28 obese adolescents with asthma, 46 obese adolescents without asthma, 58 normal-weight adolescents with asthma, and 63 healthy control subjects. Serum levels of leptin, high-molecule-weight (HMW) adiponectin, retinol binding protein 4 (RBP4), asymmetrical dimethylarginine (ADMA), and pulmonary function were qualified. The obese subjects had higher levels of leptin and ADMA but lower levels of HMW adiponectin than the normal-weight subjects with or without asthma. The subjects with asthma had higher levels of RBP4 than those without asthma. The obese adolescents with asthma had lowest forced expiratory lung volume in the first second (FEV Our present study confirmed obstructive pattern of pulmonary function characterized by the reduced FEV

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NG,NG-Dimethylarginine dihydrochloride
C8H18N4O2 · 2HCl