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Nanoscale research letters

Functionalization of Carbon Nanomaterial Surface by Doxorubicin and Antibodies to Tumor Markers.


PMID 27356561

Abstract

The actual task of oncology is effective treatment of cancer while causing a minimum harm to the patient. The appearance of polymer nanomaterials and technologies launched new applications and approaches of delivery and release of anticancer drugs. The goal of work was to test ultra dispersed diamonds (UDDs) and onion-like carbon (OLCs) as new vehicles for delivery of antitumor drug (doxorubicin (DOX)) and specific antibodies to tumor receptors. Stable compounds of UDDs and OLCs with DOX were obtained. As results of work, an effectiveness of functionalization was 2.94xa0% w/w for OLC-DOX and 2.98xa0% w/w for UDD-DOX. Also, there was demonstrated that UDD-DOX and OLC-DOX constructs had dose-dependent cytotoxic effect on tumor cells in the presence of trypsin. The survival of adenocarcinoma cells reduced from 52 to 28xa0% in case of incubation with the UDD-DOX in concentrations from 8.4-2.5 to 670-20xa0μg/ml and from 72 to 30xa0% after incubation with OLC-DOX. Simultaneously, antibodies to epidermal growth factor maintained 75xa0% of the functional activity and specificity after matrix-assisted pulsed laser evaporation deposition. Thus, the conclusion has been made about the prospects of selected new methods and approaches for creating an antitumor agent with capabilities targeted delivery of drugs.