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Journal of the American Society of Nephrology : JASN

Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.


PMID 27382987

Abstract

The amount of albumin filtered through the glomeruli and reabsorbed at the proximal tubules in normal and in diabetic kidneys is debated. The megalin/cubilin complex mediates protein reabsorption, but genetic knockout of megalin is perinatally lethal. To overcome current technical problems, we generated a drug-inducible megalin-knockout mouse line, megalin(lox/lox);Ndrg1-CreER