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Chemical biology & drug design

Docetaxel-Chitosan nanoparticles for breast cancer treatment: cell viability and gene expression study.


PMID 27390258

Abstract

Docetaxel acts through the inhibition of tubulin polymerization and reduction in the expression of BCL-2 gene. In this study, nanoparticles containing Docetaxel were prepared and their effects on the gene expression levels of BCL-2 and BAX genes were investigated. The drug was first conjugated to chitosan, and the nanoparticles were assembled in the presence of hyaluronic acid. Conjugations were confirmed by