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Immunology and cell biology

Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses.


PMID 27465674

Abstract

The CC-chemokine receptor 6 (CCR6) can be detected on naive and activated B cells. Counterintuitively, its absence accelerates the appearance of germinal centres (GCs) and increases the production of low-affinity antibodies. The detailed mechanism of CCR6 function during the humoral response has remained elusive, but previously we identified a distinct CCR6

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