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Cell death and differentiation

IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4


PMID 27472064

Abstract

Severe or prolonged inflammatory response caused by infection or biomaterials leads to delayed healing or bone repair failure. This study investigated the important roles of the proinflammatory cytokines of the interleukin-12 (IL-12) family, namely, IL-12 and IL-23, in the inflammation-mediated inhibition of bone formation in vivo. IL-12p40