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The characteristics of the serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels in gastric cancer cases.

PMID 27566604


Although carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 are the most commonly used tumor markers in gastric cancer, the differences in the characteristics of these two markers remain unclear, because most previous studies have included many patients who were positive for both markers. We analyzed the available data on 1050 patients with gastric cancer who underwent R0 resection. The background characteristics and recurrence-free survivals (RFS) were compared between the single-positive patients for CEA or CA 19-9 and double-negative patients. Among these 1050 patients, 86 patients (8.2xa0%) were positive for CEA only, 77 patients (7.3xa0%) were positive for CA 19-9 only, and 867 patients (82.6xa0%) were double negative for both markers. Patients who were elderly, male and had a differentiated histology were more commonly observed in the CEA-positive group than in the double-negative group (Pxa0=xa00.004, Pxa0=xa00.009, and Pxa0=xa00.001). The patients who were positive for either CEA or CA 19-9 had a significantly worse RFS than the patients who were negative for both (Pxa0