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The Journal of biological chemistry

Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose.


PMID 27613866

Abstract

The calcium-sensing receptor (CaSR) is activated by various cations, cationic compounds, and amino acids. In the present study we investigated the effect of glucose on CaSR in HEK293 cells stably expressing human CaSR (HEK-CaSR cells). When glucose concentration in the buffer was raised from 3 to 25 mm, a rapid elevation of cytoplasmic Ca