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Histopathology

Superficial CD34-positive fibroblastic tumour: a clinicopathological and immunohistochemical study of an additional series.


PMID 27636918

Abstract

To describe an additional series of superficial CD34-positive fibroblastic tumour, a newly described neoplasm, in order to enhance the recognition of an emerging novel entity. The clinicopathological features and immunophenotypes of 11 cases of superficial CD34-positive fibroblastic tumour were studied. There were eight males and three females, with a median age of 36 years. Tumours occurred in the thigh (n = 4), buttock (n = 3), shoulder (n = 2), upper arm (n = 1), and waist (n = 1). Histologically, all tumours were characterized by relative circumscription, pleomorphic spindled to polygonal cells with variably enlarged bizarre-appearing cells, intranuclear cytoplasmic pseudoinclusions, and extremely low mitotic activity. Immunohistochemically, neoplastic cells showed diffuse and strong expression of CD34 and focal staining of cytokeratin. Follow-up thus far has revealed an indolent clinical behaviour. Superficial CD34-positive fibroblastic tumour represents a new member of the family of cutaneous CD34-positive spindle-cell tumours. Familiarity with its clinicopathological characteristics is helpful in avoiding confusion with a variety of cutaneous mesenchymal tumours with overlapping features.