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British journal of pharmacology

Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice.


PMID 27714760

Abstract

Oxaliplatin is a platinum-based chemotherapeutic drug used as a first-line therapy for colorectal cancer. However, its use is associated with severe gastrointestinal side-effects resulting in dose limitations and/or cessation of treatment. In this study, we tested whether oxidative stress, caused by chronic oxaliplatin treatment, induces enteric neuronal damage and colonic dysmotility. Oxaliplatin (3 mg·kg Chronic in vivo oxaliplatin treatment resulted in increased formation of reactive oxygen species (O Our study is the first to provide evidence that oxidative stress is a key player in enteric neuropathy and colonic dysmotility leading to symptoms of chronic constipation observed in oxaliplatin-treated mice.