EMAIL THIS PAGE TO A FRIEND

Stem cells and development

Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury.


PMID 27762665

Abstract

Repair of calvarial bony defects remains challenging for craniofacial surgeons. Injury experiments on animal calvarial bones are widely used to study healing mechanisms and test tissue engineering approaches. Previously, we identified Gli1+ cells within the calvarial sutures as stem cells supporting calvarial bone turnover and injury repair. In this study, we tested the regenerative capacity of the suture region compared with other areas of calvarial bone. Injuries were made to mouse sagittal sutures or other areas of the calvarial bone at varying distances from the suture. Samples were collected at different time points after injury for evaluation. MicroCT and histological analyses were conducted. EdU incorporation analysis was performed to assay cell proliferation. Gli1-Cre

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

C8267 Corn oil, delivery vehicle for fat-soluble compounds