EMAIL THIS PAGE TO A FRIEND

Experimental neurology

Cisplatin-induced neuropathic pain is mediated by upregulation of N-type voltage-gated calcium channels in dorsal root ganglion neurons.


PMID 27823926

Abstract

Cisplatin is important in the treatment of various types of cancer. Although it is highly effective, it also has severe side effects, with neurotoxicity in dorsal root ganglion (DRG) neurons being one of the most common. The key mechanisms of neurotoxicity are still controversially discussed; however, disturbances of the calcium homeostasis in DRG neurons have been suggested to mediate cisplatin neurotoxicity. By using the whole-cell patch-clamp technique, immunostaining and behavioral experiments with Sprague-Dawley rats, we examined the influence of short- and long-term exposure to cisplatin on voltage-gated calcium channel (VGCC) currents (I

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

C2932
Chelerythrine chloride, ≥95% (TLC), powder
C21H18ClNO4
K1385
KN-93, ≥98% (HPLC)
C26H29ClN2O4S · H3PO4