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Diabetologia

A Tbc1d1


PMID 27826658

Abstract

TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating GLUT4 trafficking. TBC1D1 can be phosphorylated by the AMP-activated protein kinase (AMPK) on Ser Whole-body glucose homeostasis and muscle glucose uptake were assayed in mice bearing a Tbc1d1 Skeletal muscle-specific deletion of Ampkα1/a2 in mice prevented AICAR-induced hypoglycaemia and muscle glucose uptake. The Tbc1d1 TBC1D1-Ser

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A9978
AICAR, ≥98% (HPLC), powder
C9H14N4O5