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Bioorganic & medicinal chemistry

A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer.


PMID 27839660

Abstract

Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor initiation, maintenance as well as drug resistance. Therefore, targeting the CSCs along with the other cancer cells has been the most important topic during the last decade. In the present study, we evaluated the cytotoxic activity of trans-[PtCl

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