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Andrology

2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages.


PMID 27863106

Abstract

Evidence has been produced that macrophages can actively generate endocannabinoids (eCBs) in response to inflammatory stimuli. As eCBs are involved in the control of several physiological processes, including reproduction, here, we explored whether seminal levels of the eCBs, N-arachidonoylethanolamine (AEA), and 2-arachidonoylglycerol (2-AG), were higher in the presence of leukocytospermia, and were correlated with semen concentration of macrophages. The content of AEA and 2-AG was measured by high-performance liquid chromatography/mass spectrometry in seminal plasma of ejaculates from 18 leukocytospermic patients (>1 × 10

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A0580
Arachidonylethanolamide, ≥97.0% (TLC), oil
C22H37NO2