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Pharmacognosy magazine

Improved Oral Bioavailability of Total Flavonoids of


PMID 27867275

Abstract

To prepare composite phospholipid liposome (CPL) encapsulatetotal flavonoids extract from The TFDMCPL was prepared by the method of ammonium sulfate transmembrane gradients. The CPL and TFDM were separated by Sephadex-G50 chromatography. The concentration of TFDM in the CPL was detected by HPLC, then the entrapment efficiency (EE) was evaluated. And the shape, particle size, zeta potential, drug release The EE of TFDM was 84.17±2.2%, mean size of TFDMCPL was 136.2±3.7nm, polymey disperse index (PDI) was 0.158±0.015 and zeta potential was -19.8±1.2mV. TFDM-CPLwere found to enhance the release of drugs more effectively than TFDM based on the The method of ammonium sulfate transmembrane gradients is suitable for preparingTFDM-CPL. And TFDM-CPL have potential to be used to improve the bioavailability of poorly soluble drugs after oral administration. For the first time, composite phospholipid liposomes (CPL) containing total flavonoids of Dracocephalum moldavica (TFDM) were developed by method of ammonium sulfate transmembrane gradients.The TFDM-CPL was a significant improvement in bioavailability compared to the TFDM-solution, with a 10-fold increase in relative bioavailability