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Neurological research

Oxytocin provides protection against diabetic polyneuropathy in rats.


PMID 27881053

Abstract

The aim of the present study is to investigate the protective effects of oxytocin (OT) on diabetic neuropathy (DNP) in rats. Eighteen rats were used to induce diabetes using single dose streptozotocin (STZ, 60xa0mg/kg). Diabetic DNP was verified by electromyography (EMG) and motor function test on 21st day following STZ injection. Six rats served as naïve control group and received no drug (nxa0=xa06). Following EMG, diabetic rats were randomly divided into three groups and administered with either 1xa0ml/kg saline or 80xa0μg/kg OT or 160xa0μg/kg OT intraperitoneally for four weeks. Then, EMG, motor function test, biochemical analysis (plasma lipid peroxides and glutathione), histological, and immunohistochemical analysis of sciatic nerves (bax, caspase 3, caspase 9, and NGF) were performed. Diabetic rats developed neuropathy, which was apparent from decreased compound muscle action potentials amplitudes and prolonged distal latency in saline-treated rats (pxa0