EMAIL THIS PAGE TO A FRIEND

Scientific reports

Oxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1.


PMID 27982075

Abstract

Pyridinols and pyridinamines are important intermediates with many applications in chemical industry. The pyridine derivatives are in great demand as synthons for pharmaceutical products. Moreover, pyridines are used either as biologically active substances or as building blocks for polymers with unique physical properties. Application of enzymes or whole cells is an attractive strategy for preparation of hydroxylated pyridines since the methods for chemical synthesis of pyridinols, particularly aminopyridinols, are usually limited or inefficient. Burkholderia sp. MAK1 (DSM102049), capable of using pyridin-2-ol as the sole carbon and energy source, was isolated from soil. Whole cells of Burkholderia sp. MAK1 were confirmed to possess a good ability to convert different pyridin-2-amines and pyridin-2-ones into their 5-hydroxy derivatives. Moreover, several methylpyridines as well as methylated pyrazines were converted to appropriate N-oxides. In conclusion, regioselective oxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1 is a promising method for the preparation of various pyridin-5-ols and pyridin-N-oxides.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

513261
2,3,5-Collidine, 99%
C8H11N
197491
2,3-Cyclopentenopyridine, 98%
C8H9N
122505
2,3-Dihydroxypyridine, 95%
C5H5NO2
L3501
2,3-Lutidine, 99%
C7H9N
176974
2,4-Dihydroxypyridine, 97%
C5H5NO2
151351
2,5-Lutidine, 95%
C7H9N
464899
2,6-Pyridinedicarbonitrile, 97%
C7H3N3
113514
2-Amino-3-nitropyridine, 99%
C5H5N3O2
A51807
2-Amino-4,6-dimethylpyridine, 99%
C7H10N2
661325
2-Amino-4-chloropyrimidine, 97%
C4H4ClN3
CDS014293
2-amino-4-fluoropyridine, AldrichCPR
C5H5FN2
123080
2-Amino-4-methylpyridine, 99%
C6H8N2
A75684
2-Amino-5-methylpyridine, 99%
C6H8N2
725064
2-Amino-6-fluoropyridine, 98%
C5H5FN2
CDS008897
2-amino-6-hydroxypyridine, AldrichCPR
C5H6N2O
C69802
2-Chloropyridine, 99%
C5H4ClN
112429
2-Ethylpyridine, 97%
C7H9N
593311
2-Hydroxy-3-methylpyridine, 97%
C6H7NO
290114
2-Hydroxy-4-methyl-3-nitropyridine, 98%
C6H6N2O3
128740
2-Hydroxy-6-methylpyridine, 97%
C6H7NO
P42207
2-Methylpyridine N-oxide, ≥96%
C6H7NO
56413
2-Pyridinol 1-oxide, ≥98.0% (N)
C5H5NO2
686387
3-Bromo-2-hydroxypyridine, 97%
C5H4BrNO
268534
3-Hydroxy-2-methylpyridine, 99%
C6H7NO
145653
3-Methoxy-2(1H)-pyridone, 97%
C6H7NO2
512737
3-Methylpicolinonitrile, 98%
C7H6N2
107239
3-Methylpyridazine, 99%
C5H6N2
C94807
3-Pyridinecarbonitrile, 98%
C6H4N2
CDS020754
4-Bromo-2-hydroxypyridine
C5H4BrNO
673463
4-Methyl-2-pyridinecarbonitrile, 97%
C7H6N2