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Carbohydrate polymers

Role of nanostructured aggregation of chitosan derivatives on [5-methionine]enkephalin affinity.


PMID 27987934

Abstract

Affinities of quaternary ammonium-chitosan conjugates, their thiolated derivatives and corresponding nanostructured aggregates towards the hydrophilic drug [5-methionine]enkephalin were compared by Nuclear Magnetic Resonance (NMR) spectroscopic methods based on proton selective relaxation rate measurements. Nanoaggregates showed enhanced drug affinity in comparison with corresponding polymers, especially in the case of thiolated systems.

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M6638
[Met5]Enkephalin acetate salt hydrate, ≥95.0% (HPLC), powder
C27H35N5O7S · xC2H4O2 · yH2O