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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

The genotoxic potency of glycidol established from micronucleus frequency and hemoglobin adduct levels in mice.


PMID 28012894

Abstract

Glycidol is a genotoxic animal carcinogen that has raised concern due to its presence in food, as glycidyl fatty acid esters. Here we investigated the genotoxicity of glycidol in BalbC mice (0-120 mg/kg) by monitoring the induction of micronuclei in peripheral blood as a marker of chromosomal damage. The scoring of the micronuclei was assessed by flow cytometry. In the treated mice, the internal dose of glycidol, expressed as area under the concentration-time curve, AUC (mol × L