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Microbial pathogenesis

DNAzymes Dz13 target the c-jun possess antiviral activity against influenza A viruses.


PMID 28039102

Abstract

The emergence of anti-influenza A virus drugs resistant strain highlights the need for more effective therapy. Our earlier study demonstrated that c-jun, a downstream molecule of JNK, might be important in viral infections and inflammatory responses. In the present study, we explored the function of DNAzymes Dz13 that target c-jun in influenza A virus infected mice. Dz13 displayed non-toxic side effects on A549 cells and BALB/c mice. Moreover, Dz13-treated mice had enhanced survival after influenza compared with untreated mice. Simultaneously, the pulmonary inflammatory responses and viral burden were decreased in Dz13 treated mice. Furthermore, proliferation levels of infection-induced CD4

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T4376
N-p-Tosyl-L-phenylalanine chloromethyl ketone, ≥97% (TLC), powder
C17H18ClNO3S