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AAPS PharmSciTech

Formulation and Optimization of Multiparticulate Drug Delivery System Approach for High Drug Loading.


PMID 28039572

Abstract

The aim of the present work was to develop and optimize multiparticulate formulation viz. pellets of naproxen by employing QbD and risk assessment approach. Mixture design with extreme vertices was applied to the formulation with high loading of drug (about 90%) and extrusion-spheronization as a process for manufacturing pellets. Independent variables chosen were level of microcrystalline cellulose (MCC)-X