Breast cancer research and treatment

Body size from birth through adolescence in relation to risk of benign breast disease in young women.

PMID 28062981


Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18xa0year, and intervening growth, are related to BBD risk. The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013. In 1996, their mothers provided pregnancy-related data. From 2005 to 2013, participants (18xa0year+) reported whether they had ever been diagnosed with biopsy-confirmed BBD (Nxa0=xa0142 cases). Girls had greater adiposity (BMI; kg/m(2)) at 10xa0year if they were larger at birth, if mother's pre-pregnancy BMI was higher, or if gestational weight gain was greater (all pxa0