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Nature communications

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.


PMID 28067314

Abstract

Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4

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