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The Journal of cell biology

Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation.


PMID 28130292

Abstract

Dendritic cells (DCs) promote either tolerogenic or immunogenic T cell responses, the latter upon sensing microbes. Using an in vitro system, we analyzed transcriptional determinants that enable mature DCs to direct these opposing T cell outcomes. In the absence of microbial products, the transcription factor interferon regulatory factor 4 (IRF4) promotes regulatory T cell (T