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Cell death & disease

TAK1 regulates resident macrophages by protecting lysosomal integrity.


PMID 28182011

Abstract

Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1