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The Journal of neuroscience : the official journal of the Society for Neuroscience

Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.


PMID 28213441

Abstract

The secreted glycoprotein Reelin regulates embryonic brain development and adult brain functions. It has been suggested that reduced Reelin activity contributes to the pathogenesis of several neuropsychiatric and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease; however, noninvasive methods that can upregulate Reelin activity

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