EMAIL THIS PAGE TO A FRIEND

Pharmacognosy magazine

Depolarizing Effects of Daikenchuto on Interstitial Cells of Cajal from Mouse Small Intestine.


PMID 28216898

Abstract

Daikenchuto (DKT; TJ-100, TU-100), a traditional herbal medicineis used in modern medicine to treat gastrointestinal (GI) functional disorders. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the GI tract and play important roles in the regulation of GI motility. The objective of this study was to investigate the effects of DKT on the pacemaker potentials (PPs) of cultured ICCs from murine small intestine. Enzymatic digestions were used to dissociate ICCs from mouse small intestine tissues. All experiments on ICCs were performed after 12 h of culture. The whole-cell patch-clamp configuration was used to record ICC PPs (current clamp mode). All experiments were performed at 30-32°C. In current-clamp modeDKT depolarized and concentration-dependently decreased the amplitudes of PPs. Y25130 (a 5-HT These results suggest that DKT depolarizes ICC PPs in an internal or external Ca Daikenchuto (DKT) depolarized and concentration-dependently decreased the amplitudes of pacemaker potentials (PPs)Y25130 (a 5-HT

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SML0255
4-DAMP, ≥98% (HPLC)
C21H26INO2