EMAIL THIS PAGE TO A FRIEND

Biochemical and biophysical research communications

PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species.


PMID 28257842

Abstract

Excessive generation of reactive oxygen species (ROS) is one of the main causes of myocardial ischemia-reperfusion (I/R) injury. In this study, we investigated the role of protein kinase C-interacting cousin of thioredoxin (PICOT; Grx3) during myocardial I/R using PICOT transgenic (TG) and knockdown (KD) mice. Infarction and apoptosis were attenuated in PICOT TG mice but exacerbated in PICOT KD mice upon I/R. In parallel, I/R-induced generation of ROS was attenuated in PICOT TG mice but exacerbated in PICOT KD mice. Angiotensin II (AngII)-mediated increases in ROS and free iron levels were also attenuated in cardiomyocytes isolated from PICOT TG mice but exacerbated in cardiomyocytes from PICOT KD mice. Accordingly, H

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D6883
2′,7′-Dichlorofluorescin diacetate, ≥97%
C24H16Cl2O7