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Proceedings of the National Academy of Sciences of the United States of America

Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in


PMID 28265091

Abstract

Forkhead Box (Fox) proteins share the Forkhead domain, a winged-helix DNA binding module, which is conserved among eukaryotes from yeast to humans. These sequence-specific DNA binding proteins have been primarily characterized as transcription factors regulating diverse cellular processes from cell cycle control to developmental fate, deregulation of which contributes to developmental defects, cancer, and aging. We recently identified