EMAIL THIS PAGE TO A FRIEND

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells.


PMID 28280421

Abstract

The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53-mediated reactive oxygen species (ROS) production. Recently, several studies have suggested that PIG3 may play a role in various types of cancer. However, the functional significance of PIG3 in cancer remains unclear. Here, we found that PIG3 was highly expressed in human colon cancer cell lines compared to normal colonderived fibroblasts. Therefore, we attempted to elucidate the functional role of PIG3 in colon cancer. PIG3 overexpression increases the colony formation, migration and invasion ability of HCT116 colon cancer cells. Conversely, these tumorigenic abilities were significantly decreased in

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

EHU059861 MISSION® esiRNA, esiRNA human TP53I3 (esiRNA1)