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Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Zinc inhibition of pyruvate kinase of M-type isozyme.


PMID 28293755

Abstract

Inhibitory effect of Zn on the pyruvate kinase of M (muscle)-type isozyme was analyzed for the purpose of elucidating the cytotoxicity of Zn. Zn inhibited pyruvate kinase uncompetitively with respect to the substrate PEP, and competitively with respect to ADP. Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn

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