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The Journal of pharmacy and pharmacology

Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-hydroxyflavone and 7,8-dihydroxyflavone.


PMID 28295316

Abstract

Flavonoids are a class of compounds that having the benzo-γ-pyrone skeleton, which possess anti-inflammatory properties in vitro and in vivo. The aim of this study was to investigate the inhibition of two flavonoids 7-hydroxyflavone (HF) and 7,8-dihydroxyflavone (DHF) on the production of pro-inflammatory mediators in RAW264.7 cells activated by lipopolysaccharides (LPS). For this purpose, we selected four pro-inflammatory mediators including nitric oxide (NO), prostaglandin E In this regard, we showed that HF and DHF dose-dependently reduced the production of NO, PGE Consider together, these findings suggest that DHF and HF can inhibit LPS-induced inflammation via attenuating the production of NO, PGE

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H4530
7-Hydroxyflavone, ≥98%
C15H10O3