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Free radical biology & medicine

In vivo EPR pharmacokinetic evaluation of the redox status and the blood brain barrier permeability in the SOD1


PMID 28366802

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the motor pathways of the central nervous system. Although a number of pathophysiological mechanisms have been described in the disease, post mortem and animal model studies indicate blood-brain barrier (BBB) disruption and elevated production of reactive oxygen species as major contributors to disease pathology. In this study, the BBB permeability and the brain tissue redox status of the SOD1

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