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Genome research

Accumulation of RNA on chromatin disrupts heterochromatic silencing.


PMID 28404620

Abstract

Long noncoding RNAs (lncRNAs) play a conserved role in regulating gene expression, chromatin dynamics, and cell differentiation. They serve as a platform for RNA interference (RNAi)-mediated heterochromatin formation or DNA methylation in many eukaryotic organisms. We found in