EMAIL THIS PAGE TO A FRIEND

British journal of pharmacology

Factors influencing biased agonism in recombinant cells expressing the human α


PMID 28444738

Abstract

Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β-arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding factors contributing to bias. We have examined bias at human α Intracellular Ca Noradrenaline, phenylephrine, methoxamine and A61603 increased Ca We have shown that while adrenergic agonists display bias at human α