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Scientific reports

Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males.


PMID 28490809

Abstract

Impaired estrogens action is associated with features of the metabolic syndrome in animal models and humans. We sought to determine whether disruption of hepatic estrogens action in adult male mice could recapitulate aspects of the metabolic syndrome to understand the mechanistic basis for the phenotype. We found 17β-estradiol (E

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