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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Studies on curative efficacy of monoterpene eugenol on anti- leukemic drug arsenic trioxide induced cardiotoxicity.


PMID 28494415

Abstract

Arsenic trioxide (As In this study, the cardioprotective effect of eugenol on cardiac electrical conductivity, tissue electrolytes, myocardial markers, antioxidant system, lipid peroxidation and nitric oxide production was investigated in male Wistar rats treated with arsenic trioxide. The Inductively coupled plasma emission spectroscopic (ICP-OES) analysis pointed out the accumulation of arsenic in heart tissue. The rats administered with arsenic trioxide (4mg/kg body wt) exhibited myocardial damage that was manifested by the elevation of cardiac markers (LDH, CK-MB) enzymes and deterioration in the antioxidant enzymes (GSH, GST, GPx). Combination treatment with eugenol (5mg/kg of body wt) upholds the tissue antioxidant level, Na Our in vivo experimental findings suggest that monoterpenoid eugenol could be a potent and novel cytoprotective agent of clinical application against As

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