EMAIL THIS PAGE TO A FRIEND

Cancer research

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.


PMID 28512249

Abstract

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes tuberous sclerosis complex (TSC)1 or TSC2. Here we report that p62 is a critical mediator of TSC2-driven tumorigenesis, as Tsc2

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

B2515
L-Buthionine-sulfoximine, ≥97% (TLC)
C8H18N2O3S