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Genetics

A Novel Histone Crosstalk Pathway Important for Regulation of UV-Induced DNA Damage Repair in


PMID 28522541

Abstract

Histone post-translational modifications play vital roles in a variety of nuclear processes, including DNA repair. It has been previously shown that histone H3K79 methylation is important for the cellular response to DNA damage caused by ultraviolet (UV) radiation, with evidence that specific methylation states play distinct roles in UV repair. Here, we report that H3K79 methylation is reduced in response to UV exposure in