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Scientific reports

Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.


PMID 28526879

Abstract

Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation. However, how lineages are transformed and how chemoresistance is acquired by CRCs remain largely unknown. In this report, we demonstrated that the RNA-binding protein Musashi-1 enhanced the development of CD44