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Drug metabolism and disposition: the biological fate of chemicals

Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice.


PMID 28546505

Abstract

Phenobarbital (PB) promotes liver tumorigenesis in rodents, in part through activation of the constitutive androstane receptor (CAR) and the consequent changes in hepatic gene expression and increases in hepatocyte proliferation. A typical effect of CAR activation by PB is a marked induction of

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P5178
Phenobarbital sodium salt
C12H11N2NaO3