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Journal of neurosurgical sciences

Topically-administered acetyl-L-carnitine increases sciatic nerve regeneration and improves functional recovery after tubulization of transected short nerve gaps.


PMID 28555486

Abstract

Peripheral nerve injuries repair is still among the most challenging and concern-raising tasks in neurosurgery. The effect of an acetyl-L-carnitin-loaded silicone tube as an in-situ delivery system in defects bridging was studied using a rat sciatic nerve regeneration model. A 10-mm sciatic nerve defect was bridged using a silicone tube (SIL/ALC) filled with 10 µL acetyl-L-carnitine (100 ng/mL). In the control group (SIL), the tube was filled with the same volume of the phosphate-buffered solution. The regenerated fibers were studied 4, 8, 12 and 16 weeks after surgery. The functional study confirmed faster recovery of the regenerated axons in acetyl-L-carnitine treated than control group (P<0.05). The mean ratios of gastrocnemius muscles weight were measured. There was a statistically significant difference between the muscle weight ratios of SIL/ALC and SIL groups (P<0.05). Morphometric indices of regenerated fibers showed that the number and diameter of the myelinated fibers in SIL/ALC were significantly higher than in the control group. In immuohistochemistry, the location of reactions to S-100 in the SIL/ALC group was clearly more positive than in the SIL group. Acetyl-L-carnitine, when loaded in a silicone tube, can bring to an improvement in functional recovery and quantitative morphometric indices of sciatic nerve.

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A6706
O-Acetyl-L-carnitine hydrochloride, ≥99% (titration), powder
C9H17NO4 · HCl