EMAIL THIS PAGE TO A FRIEND

Proceedings of the National Academy of Sciences of the United States of America

Follistatin is critical for mouse uterine receptivity and decidualization.


PMID 28559342

Abstract

Embryo implantation remains a significant challenge for assisted reproductive technology, with implantation failure occurring in ∼50% of in vitro fertilization attempts. Understanding the molecular mechanisms underlying uterine receptivity will enable the development of new interventions and biomarkers. TGFβ family signaling in the uterus is critical for establishing and maintaining pregnancy. Follistatin (FST) regulates TGFβ family signaling by selectively binding TGFβ family ligands and sequestering them. In humans, FST is up-regulated in the decidua during early pregnancy, and women with recurrent miscarriage have lower endometrial expression of FST during the luteal phase. Because global knockout of

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

19589
L-2,4-Diaminobutyric acid monohydrochloride, ≥98.0% (AT), ≥98.0% (TLC)
C4H10N2O2 · HCl