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Scientific reports

Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2.


PMID 28600551

Abstract

AMP-activated protein kinase (AMPK) is a pivotal cellular energy sensor. It is activated by stresses that cause depletion of energy and initiates adaptive responses by regulating metabolism balance. AMPK forms αβγ heterotrimer. In fission yeast, activation of AMPK mainly depends on the phosphorylation of AMPKα subunit Ssp2 at Thr