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The Journal of pathology

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.


PMID 28603917

Abstract

Castration-resistant prostate cancer is a lethal disease. The cell type(s) that survive androgen deprivation remain poorly described, despite global efforts to understand the various mechanisms of therapy resistance. We recently identified in wild-type (WT) mouse prostates a rare population of luminal progenitor cells that we called LSC